CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C
Functional Family Anthranilate phosphoribosyltransferase

Enzyme Information

2.4.2.18
Anthranilate phosphoribosyltransferase.
based on mapping to UniProt A5U4M0
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).

UniProtKB Entries (1)

A5U4M0
TRPD_MYCTA
Mycobacterium tuberculosis H37Ra
Anthranilate phosphoribosyltransferase

PDB Structure

PDB 4ZOJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibitor bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD).
Evans, G.L., Baker, E.N., Lott, J.S.
To be Published