CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q13153
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13153
PAK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase PAK 1

PDB Structure

PDB 4ZJJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor.
Karpov, A.S., Amiri, P., Bellamacina, C., Bellance, M.H., Breitenstein, W., Daniel, D., Denay, R., Fabbro, D., Fernandez, C., Galuba, I., Guerro-Lagasse, S., Gutmann, S., Hinh, L., Jahnke, W., Klopp, J., Lai, A., Lindvall, M.K., Ma, S., Mobitz, H., Pecchi, S., Rummel, G., Shoemaker, K., Trappe, J., Voliva, C., Cowan-Jacob, S.W., Marzinzik, A.L.
Acs Med.Chem.Lett.