CATH Classification

Domain Context

CATH Clusters

Superfamily Extracellular Endonuclease, subunit A
Functional Family Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Enzyme Information

3.1.4.39
Alkylglycerophosphoethanolamine phosphodiesterase.
based on mapping to UniProt Q13822
1-alkyl-sn-glycero-3-phosphoethanolamine + H(2)O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine.
-!- Also acts on acyl and choline analogs.

UniProtKB Entries (1)

Q13822
ENPP2_HUMAN
Homo sapiens
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

PDB Structure

PDB 4ZGA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
Stein, A.J., Bain, G., Prodanovich, P., Santini, A.M., Darlington, J., Stelzer, N.M., Sidhu, R.S., Schaub, J., Goulet, L., Lonergan, D., Calderon, I., Evans, J.F., Hutchinson, J.H.
Mol.Pharmacol.