CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.660.10
Functional Family Renalase

Enzyme Information

1.6.3.5
Renalase.
based on mapping to UniProt Q48MT7
(1) 1,2-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2). (2) 1,6-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2).
-!- Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta- NAD(P)(+). -!- These isomeric forms, generated by nonspecific reduction of beta- NAD(P)(+) or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.

UniProtKB Entries (1)

Q48MT7
RNLS_PSE14
Pseudomonas savastanoi pv. phaseolicola 1448A
Renalase

PDB Structure

PDB 4ZCD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Bacterial Renalase: Structure and Kinetics of an Enzyme with 2- and 6-Dihydro-beta-NAD(P) Oxidase Activity from Pseudomonas phaseolicola.
Hoag, M.R., Roman, J., Beaupre, B.A., Silvaggi, N.R., Moran, G.R.
Biochemistry