CATH Classification

Domain Context

CATH Clusters

Superfamily Uracil-DNA glycosylase-like domain
Functional Family Uracil-DNA glycosylase, family 4

Enzyme Information

3.2.2.27
Uracil-DNA glycosylase.
based on mapping to UniProt Q96YD0
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.
-!- Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. -!- Uracil-DNA glycosylase (EC 3.2.2.27) and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolyzing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalyzing the removal of mis-incorporated uracil from DNA.

UniProtKB Entries (1)

Q96YD0
UDGA_SULTO
Sulfolobus tokodaii str. 7
Type-4 uracil-DNA glycosylase

PDB Structure

PDB 4ZBX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of family 4 uracil-DNA glycosylase from Sulfolobus tokodaii and a function of tyrosine 170 in DNA binding
Kawai, A., Higuchi, S., Tsunoda, M., Nakamura, K.T., Yamagata, Y., Miyamoto, S.
Febs Lett.