CATH Classification

Domain Context

CATH Clusters

Superfamily Uracil-DNA glycosylase-like domain
Functional Family G/T mismatch-specific thymine DNA glycosylase

Enzyme Information
Thymine-DNA glycosylase.
based on mapping to UniProt Q13569
Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine.
-!- Thymine-DNA glycosylase is part of the DNA-repair machinery. -!- Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair. -!- The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T.

UniProtKB Entries (1)

Homo sapiens
G/T mismatch-specific thymine DNA glycosylase

PDB Structure

PDB 4Z47
External Links
Primary Citation
Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA.
Malik, S.S., Coey, C.T., Varney, K.M., Pozharski, E., Drohat, A.C.
Nucleic Acids Res.