CATH Classification

Domain Context

CATH Clusters

Superfamily Carbohydrate-binding module superfamily 5/12
Functional Family

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt P11797
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

P11797
CHIB_SERMA
Serratia marcescens
Chitinase B

PDB Structure

PDB 4Z2K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase
Sugawara, A., Maita, N., Gouda, H., Yamamoto, T., Hirose, T., Kimura, S., Saito, Y., Nakano, H., Kasai, T., Nakano, H., Shiomi, K., Hirono, S., Watanabe, T., Taniguchi, H., Omura, S., Sunazuka, T.
J.Med.Chem.