CATH Classification

Domain Context

CATH Clusters

Superfamily KEN domain
Functional Family Serine/threonine-protein kinase/endoribonuclease IRE1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O75460
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
3.1.26.-
Endoribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt O75460

UniProtKB Entries (1)

O75460
ERN1_HUMAN
Homo sapiens
Serine/threonine-protein kinase/endoribonuclease IRE1

PDB Structure

PDB 4YZC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1 alpha Endoribonuclease Activity.
Concha, N.O., Smallwood, A., Bonnette, W., Totoritis, R., Zhang, G., Federowicz, K., Yang, J., Qi, H., Chen, S., Campobasso, N., Choudhry, A.E., Shuster, L.E., Evans, K.A., Ralph, J., Sweitzer, S., Heerding, D.A., Buser, C.A., Su, D.S., DeYoung, M.P.
Mol.Pharmacol.