CATH Classification

Domain Context

CATH Clusters

Superfamily DNA integrity scanning linker region
Functional Family DNA integrity scanning protein DisA

Enzyme Information

2.7.7.85
Diadenylate cyclase.
based on mapping to UniProt Q9WY43
2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate.
-!- Cyclic di-3',5'-adenylate is a bioactive molecule produced by some bacteria and archaea, which may function as a secondary signaling molecule. -!- The intracellular bacterial pathogen Listeria monocytogenes secretes it into the host's cytosol, where it triggers a cytosolic pathway of innate immunity.

UniProtKB Entries (1)

Q9WY43
DISA_THEMA
Thermotoga maritima MSB8
DNA integrity scanning protein DisA

PDB Structure

PDB 4YXJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.
Muller, M., Deimling, T., Hopfner, K.P., Witte, G.
Biochem.J.