CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family

Enzyme Information

3.4.22.38
Cathepsin K.
based on mapping to UniProt P43235
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
-!- Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P43235
CATK_HUMAN
Homo sapiens
Cathepsin K

PDB Structure

PDB 4YV8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts.
Aguda, A.H., Lavallee, V., Cheng, P., Bott, T.M., Meimetis, L.G., Law, S., Nguyen, N.T., Williams, D.E., Kaleta, J., Villanueva, I., Davies, J., Andersen, R.J., Brayer, G.D., Bromme, D.
J.Nat.Prod.