CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

Enzyme Information

2.7.12.1
Dual-specificity kinase.
based on mapping to UniProt Q13627
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q13627
DYR1A_HUMAN
Homo sapiens
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB Structure

PDB 4YU2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of DYRK1A with harmine-derivatized AnnH-75 inhibitor
Chaikuad, A., Wurzlbauer, A., Nowak, R., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bracher, F., Knapp, S., Structural Genomics Consortium (SGC)
To Be Published