CATH Classification

Domain Context

CATH Clusters

Superfamily Alkaline Phosphatase, subunit A
Functional Family Alkaline phosphatase

Enzyme Information

3.1.3.1
Alkaline phosphatase.
based on mapping to UniProt P00634
A phosphate monoester + H(2)O = an alcohol + phosphate.
-!- Active at a high pH optimum. -!- Wide specificity. -!- Also catalyzes transphosphorylations. -!- Some enzymes hydrolyze diphosphate (cf. EC 3.6.1.1).

UniProtKB Entries (1)

P00634
PPB_ECOLI
Escherichia coli K-12
Alkaline phosphatase

PDB Structure

PDB 4YR1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Extensive site-directed mutagenesis reveals interconnected functional units in the Alkaline Phosphatase active site.
Sunden, F., Peck, A., Salzman, J., Ressl, S., Herschlag, D.
Elife