CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1170.60
Functional Family DNA polymerase eta

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9Y253
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9Y253
POLH_HUMAN
Homo sapiens
DNA polymerase eta

PDB Structure

PDB 4YP3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
J.Biol.Chem.