CATH Classification

Domain Context

CATH Clusters

Superfamily Regulator of G-protein Signalling 4, domain 2
Functional Family G protein-coupled receptor kinase

Enzyme Information

2.7.11.16
[G-protein-coupled receptor] kinase.
based on mapping to UniProt P32298
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.
-!- All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. -!- (cf. EC 2.7.11.14 and EC 2.7.11.15).

UniProtKB Entries (1)

P32298
GRK4_HUMAN
Homo sapiens
G protein-coupled receptor kinase 4

PDB Structure

PDB 4YHJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.
Allen, S.J., Parthasarathy, G., Darke, P.L., Diehl, R.E., Ford, R.E., Hall, D.L., Johnson, S.A., Reid, J.C., Rickert, K.W., Shipman, J.M., Soisson, S.M., Zuck, P., Munshi, S.K., Lumb, K.J.
J.Biol.Chem.