CATH Classification

Domain Context

CATH Clusters

Superfamily HAD superfamily/HAD-like
Functional Family Carboxy-terminal domain RNA polymerase II polypeptide A small

Enzyme Information

3.1.3.16
Protein-serine/threonine phosphatase.
based on mapping to UniProt Q9GZU7
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (1)

Q9GZU7
CTDS1_HUMAN
Homo sapiens
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

PDB Structure

PDB 4YGY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Chemical Tools To Decipher Regulation of Phosphatases by Proline Isomerization on Eukaryotic RNA Polymerase II.
Mayfield, J.E., Fan, S., Wei, S., Zhang, M., Li, B., Ellington, A.D., Etzkorn, F.A., Zhang, Y.J.
Acs Chem.Biol.