CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family DNA-directed RNA polymerase subunit alpha

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P0A7Z6
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (2)

P00579
RPOD_ECOLI
Escherichia coli K-12
RNA polymerase sigma factor RpoD
P0A8T8
RPOC_ECO57
Escherichia coli O157:H7
DNA-directed RNA polymerase subunit beta'

PDB Structure

PDB 4YG2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-ray crystal structure of Escherichia coli RNA polymerase sigma70 holoenzyme
Murakami, K.S.
J. Biol. Chem.