CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1360 | Gyrase A; domain 2 |
|
3.30.1360.10 | RNA polymerase, RBP11-like subunit |
Domain Context
CATH Clusters
| Superfamily | RNA polymerase, RBP11-like subunit |
| Functional Family | DNA-directed RNA polymerase subunit alpha |
Enzyme Information
| 2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt A7ZSI4
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
|
UniProtKB Entries (2)
| P00579 |
RPOD_ECOLI
Escherichia coli K-12
RNA polymerase sigma factor RpoD
|
| A7ZSI4 |
RPOA_ECO24
Escherichia coli O139:H28 str. E24377A
DNA-directed RNA polymerase subunit alpha
|
PDB Structure
| PDB | 4YFX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein.
J.Med.Chem.
|