CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450
Functional Family steroid 21-hydroxylase isoform X1

Enzyme Information

1.14.14.16
Steroid 21-monooxygenase.
based on mapping to UniProt P08686
A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O(2) = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H(2)O.
-!- For the conversion of progesterone and 17-alpha-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol. -!- Involved in the biosynthesis of the hormones aldosterone and cortisol. -!- The electron donor is EC 1.6.2.4. -!- Formerly EC 1.14.1.8, EC 1.14.99.10 and EC 1.99.1.11.

UniProtKB Entries (1)

P08686
CP21A_HUMAN
Homo sapiens
Steroid 21-hydroxylase

PDB Structure

PDB 4Y8W
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYMEPROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.
Pallan, P.S., Wang, C., Lei, L., Yoshimoto, F.K., Auchus, R.J., Waterman, M.R., Guengerich, F.P., Egli, M.
J.Biol.Chem.