CATH Classification

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase 9A

Enzyme Information

3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt O76083
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

O76083
PDE9A_HUMAN
Homo sapiens
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

PDB Structure

PDB 4Y86
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor.
Huang, M., Shao, Y., Hou, J., Cui, W., Liang, B., Huang, Y., Li, Z., Wu, Y., Zhu, X., Liu, P., Wan, Y., Ke, H., Luo, H.B.
Mol.Pharmacol.