CATH Classification

Domain Context

CATH Clusters

Superfamily RNA polymerase alpha subunit dimerisation domain
Functional Family DNA-directed RNA polymerase subunit B

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P08518
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P20435
RPAB2_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerases I, II, and III subunit RPABC2

PDB Structure

PDB 4Y7N
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex.
Wang, L., Zhou, Y., Xu, L., Xiao, R., Lu, X., Chen, L., Chong, J., Li, H., He, C., Fu, X.D., Wang, D.
Nature