CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.960.20
Functional Family Genome polyprotein

Enzyme Information

3.4.22.28
Picornain 3C.
based on mapping to UniProt P12296
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
-!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.
2.7.7.48
RNA-directed RNA polymerase.
based on mapping to UniProt P12296
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
3.6.4.13
RNA helicase.
based on mapping to UniProt P12296
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

P12296
POLG_ENMGO
Mengo virus
Genome polyprotein

PDB Structure

PDB 4Y3C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
van der Linden, L., Vives-Adrian, L., Selisko, B., Ferrer-Orta, C., Liu, X., Lanke, K., Ulferts, R., De Palma, A.M., Tanchis, F., Goris, N., Lefebvre, D., De Clercq, K., Leyssen, P., Lacroix, C., Purstinger, G., Coutard, B., Canard, B., Boehr, D.D., Arnold, J.J., Cameron, C.E., Verdaguer, N., Neyts, J., van Kuppeveld, F.J.
Plos Pathog.