CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Probable 4-aminobutyrate aminotransferase, mitochondrial

Enzyme Information

2.6.1.19
4-aminobutyrate--2-oxoglutarate transaminase.
based on mapping to UniProt P80147
4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
-!- Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate.
2.6.1.22
(S)-3-amino-2-methylpropionate transaminase.
based on mapping to UniProt P80147
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3- oxopropanoate + L-glutamate.
-!- Also acts on beta-alanine and other omega-amino acids having carbon chains between 2 and 5. -!- The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.40, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.

UniProtKB Entries (1)

P80147
GABT_PIG
Sus scrofa
4-aminobutyrate aminotransferase, mitochondrial

PDB Structure

PDB 4Y0I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
GABA-aminotransferase inactivated by conformationally-restricted inactivator
Lee, H.V., Dustin, D.H., Wu, R., Emma, D., Sanishvili, R., Liu, D., Neil, K., Silverman, R.B.
To Be Published