CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P43403
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P43403
ZAP70_HUMAN
Homo sapiens
Tyrosine-protein kinase ZAP-70

PDB Structure

PDB 4XZ1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.
Visperas, P.R., Winger, J.A., Horton, T.M., Shah, N.H., Aum, D.J., Tao, A., Barros, T., Yan, Q., Wilson, C.G., Arkin, M.R., Weiss, A., Kuriyan, J.
Biochem. J.