CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.940.10
Functional Family

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q9EVV4
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q9EZJ8
SIGA_THEAQ
Thermus aquaticus
RNA polymerase sigma factor SigA

PDB Structure

PDB 4XLP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of a bacterial RNA polymerase holoenzyme open promoter complex.
Bae, B., Feklistov, A., Lass-Napiorkowska, A., Landick, R., Darst, S.A.
Elife