CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.10 Ribbon
Topology 2.10.60 CD59
Homologous Superfamily 2.10.60.10 CD59

Domain Context

CATH Clusters

Superfamily CD59
Functional Family TGF-beta receptor type-2

Enzyme Information

2.7.11.30
Receptor protein serine/threonine kinase.
based on mapping to UniProt P37173
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P37173
TGFR2_HUMAN
Homo sapiens
TGF-beta receptor type-2

PDB Structure

PDB 4XJJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Extracellular domain of type II Transforming Growth Factor Beta receptor in complex with 2-(2-Hydroxyethyl)NDSB-201
Wangkanont, K., Forest, K.T., Kiessling, L.L.
to be published