CATH Classification

Domain Context

CATH Clusters

Superfamily 6.10.240.10
Functional Family

Enzyme Information

1.1.1.382
Ketol-acid reductoisomerase (NAD(+)).
based on mapping to UniProt Q64BR7
(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) = (2S)-2-hydroxy-2-methyl- 3-oxobutanoate + NADH.
-!- The enzyme, characterized from the bacteria Thermacetogenium phaeum and Desulfococcus oleovorans and from the archaeon Archaeoglobus fulgidus, is specific for NADH (cf. EC 1.1.1.86 and EC 1.1.1.383).

UniProtKB Entries (1)

Q64BR7
ILVC_UNCAG
uncultured archaeon GZfos26G2
Ketol-acid reductoisomerase (NAD(+))

PDB Structure

PDB 4XDY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases.
Cahn, J.K., Brinkmann-Chen, S., Spatzal, T., Wiig, J.A., Buller, A.R., Einsle, O., Hu, Y., Ribbe, M.W., Arnold, F.H.
Biochem.J.