CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.360
Functional Family

Enzyme Information

1.10.5.1
Ribosyldihydronicotinamide dehydrogenase (quinone).
based on mapping to UniProt P16083
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D- ribofuranosyl)nicotinamide + a quinol.
-!- Unlike EC 1.6.5.2, this quinone reductase cannot use NADH or NADPH; instead it uses N-ribosyl- and N-alkyldihydronicotinamides. -!- Polycyclic aromatic hydrocarbons, such as benz[a]anthracene, and the estrogens 17-beta-estradiol and diethylstilbestrol are potent inhibitors, but dicoumarol is only a very weak inhibitor. -!- This enzyme can catalyze both 2-electron and 4-electron reductions, but one-electron acceptors, such as potassium ferricyanide, cannot be reduced. -!- Formerly EC 1.10.99.2.

UniProtKB Entries (1)

P16083
NQO2_HUMAN
Homo sapiens
Ribosyldihydronicotinamide dehydrogenase [quinone]

PDB Structure

PDB 4XDH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Role of Quinone Reductase 2 in the Antimalarial Properties of Indolone-Type Derivatives.
Cassagnes, L.E., Rakotoarivelo, N., Sirigu, S., Perio, P., Najahi, E., Chavas, L.M., Thompson, A., Gayon, R., Ferry, G., Boutin, J.A., Valentin, A., Reybier, K., Nepveu, F.
Molecules