CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Coagulation factor XII

Enzyme Information

3.4.21.38
Coagulation factor XIIa.
based on mapping to UniProt P00748
Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.
-!- Also activates plasma prekallikrein and plasminogen. -!- Formed from the proenzyme, factor XII, by plasma kallikrein or factor XIIa. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00748
FA12_HUMAN
Homo sapiens
Coagulation factor XII

PDB Structure

PDB 4XDE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Coagulation factor XII protease domain crystal structure.
Pathak, M., Wilmann, P., Awford, J., Li, C., Hamad, B.K., Fischer, P.M., Dreveny, I., Dekker, L.V., Emsley, J.
J.Thromb.Haemost.