CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family HEN methyltransferase 1

Enzyme Information

2.1.1.n8
Small RNA 2'-O-methyltransferase.
based on mapping to UniProt Q5T8I9
S-adenosyl-L-methionine + small RNA = S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide.
-!- Adds a methyl group to the ribose of the last nucleotide of small RNAs (sRNAs). -!- This protects the 3'-end of sRNAs from uridylation activity and subsequent degradation. -!- Can methylates 3'-end of microRNAs (miRNAs), small interfering RNAs (siRNas) and trans-acting small interfering RNAs (ta-siRNAs).

UniProtKB Entries (1)

Q5T8I9
HENMT_HUMAN
Homo sapiens
Small RNA 2'-O-methyltransferase

PDB Structure

PDB 4XCX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human C1ORF59 in complex with SAH
Walker, J.R., Zeng, H., Dong, A., Li, Y., Wernimont, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)
To be published