CATH Classification

Domain Context

CATH Clusters

Superfamily POLO box domain
Functional Family Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21
Polo kinase.
based on mapping to UniProt Q9NYY3
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q9NYY3
PLK2_HUMAN
Homo sapiens
Serine/threonine-protein kinase PLK2

PDB Structure

PDB 4XB0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analysis of the polo-box domain of human Polo-like kinase 2
Kim, J.H., Ku, B., Lee, K.S., Kim, S.J.
Proteins