CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase M42, domain 2
Functional Family

Enzyme Information

3.4.11.15
Aminopeptidase Y.
based on mapping to UniProt Q8TZW4
Preferentially, release of N-terminal lysine.
-!- Inhibited by Zn(2+) and Mn(2+). -!- Hydrolyzes L-lysyl-4-nitroanilide and, more slowly, L-arginyl-4- nitroanilide. -!- Belongs to peptidase family M28B.

UniProtKB Entries (1)

Q8TZW4
AMPK_PYRFU
Pyrococcus furiosus DSM 3638
Lysyl aminopeptidase

PDB Structure

PDB 4X8I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Tuned by metals: the TET peptidase activity is controlled by 3 metal binding sites.
Colombo, M., Girard, E., Franzetti, B.
Sci Rep