CATH Classification

Domain Context

CATH Clusters

Superfamily Protein-arginine deiminase, central domain
Functional Family Protein-arginine deiminase type-2

Enzyme Information

3.5.3.15
Protein-arginine deiminase.
based on mapping to UniProt Q9UM07
Protein L-arginine + H(2)O = protein L-citrulline + NH(3).
-!- Also acts on N-acyl-L-arginine and, more slowly, on L-arginine esters.

UniProtKB Entries (1)

Q9UM07
PADI4_HUMAN
Homo sapiens
Protein-arginine deiminase type-4

PDB Structure

PDB 4X8G
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Lewis, H.D., Liddle, J., Coote, J.E., Atkinson, S.J., Barker, M.D., Bax, B.D., Bicker, K.L., Bingham, R.P., Campbell, M., Chen, Y.H., Chung, C.W., Craggs, P.D., Davis, R.P., Eberhard, D., Joberty, G., Lind, K.E., Locke, K., Maller, C., Martinod, K., Patten, C., Polyakova, O., Rise, C.E., Rudiger, M., Sheppard, R.J., Slade, D.J., Thomas, P., Thorpe, J., Yao, G., Drewes, G., Wagner, D.D., Thompson, P.R., Prinjha, R.K., Wilson, D.M.
Nat.Chem.Biol.