CATH Classification

Domain Context

CATH Clusters

Superfamily Glycogen Phosphorylase B;
Functional Family

Enzyme Information

2.4.1.70
Poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase.
based on mapping to UniProt A0A0H2WWV6
n UDP-N-acetyl-alpha-D-glucosamine + 4-O-(D-ribitylphospho)(n)-di((2R)-1- glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D- glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-(2-N- acetyl-alpha-D-glucosaminyl-D-ribitylphospho)(n)-di((2R)-1- glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D- glucosaminyl-diphospho-ditrans,octacis-undecaprenol.
-!- Involved in the biosynthesis of poly(ribitol phosphate) teichoic acids in the cell wall of the bacterium Staphylococcus aureus. -!- This enzyme adds an N-acetyl-alpha-D-glucosamine to the hydroxyl group at the 2 position of the ribitol phosphate units. -!- Cf. EC 2.4.1.355.

UniProtKB Entries (1)

A0A0H2WWV6
TARM_STAAC
Staphylococcus aureus subsp. aureus COL
Poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase

PDB Structure

PDB 4X7P
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid alpha-glycosyltransferase.
Sobhanifar, S., Worrall, L.J., Gruninger, R.J., Wasney, G.A., Blaukopf, M., Baumann, L., Lameignere, E., Solomonson, M., Brown, E.D., Withers, S.G., Strynadka, N.C.
Proc.Natl.Acad.Sci.USA