CATH Domain 4x63B00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.130	7 Propeller
	2.130.10	Methylamine Dehydrogenase; Chain H
	2.130.10.10	YVTN repeat-like/Quinoprotein amine dehydrogenase

Domain Context

CATH Clusters

Superfamily	YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family	Methylosome protein 50

Enzyme Information

UniProtKB Entries (1)

MEP50_HUMAN

Homo sapiens

Methylosome protein 50

PDB Structure

PDB	4X63
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Chan-Penebre, E., Kuplast, K.G., Majer, C.R., Boriack-Sjodin, P.A., Wigle, T.J., Johnston, L.D., Rioux, N., Munchhof, M.J., Jin, L., Jacques, S.L., West, K.A., Lingaraj, T., Stickland, K., Ribich, S.A., Raimondi, A., Scott, M.P., Waters, N.J., Pollock, R.M., Smith, J.J., Barbash, O., Pappalardi, M., Ho, T.F., Nurse, K., Oza, K.P., Gallagher, K.T., Kruger, R., Moyer, M.P., Copeland, R.A., Chesworth, R., Duncan, K.W. Nat.Chem.Biol.