CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase receptor Tie-1

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q02763
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q02763
TIE2_HUMAN
Homo sapiens
Angiopoietin-1 receptor

PDB Structure

PDB 4X3J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Selection of fragments for kinase inhibitor design: decoration is key.
Czodrowski, P., Holzemann, G., Barnickel, G., Greiner, H., Musil, D.
J.Med.Chem.