CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.47.10
Functional Family Acetyl-CoA acetyltransferase

Enzyme Information

2.3.1.9
Acetyl-CoA C-acetyltransferase.
based on mapping to UniProt P76461
2 acetyl-CoA = CoA + acetoacetyl-CoA.
-!- The enzyme, found in both eukaryotes and prokaryotes, catalyzes the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms. -!- The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA. -!- In the second step the acyl group is transferred to an acetyl-CoA molecule. -!- Cf. EC 2.3.1.16.

UniProtKB Entries (1)

P76461
ATOB_ECOLI
Escherichia coli K-12
Acetyl-CoA acetyltransferase

PDB Structure

PDB 4WYS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum
Kim, S., Jang, Y.S., Ha, S.C., Ahn, J.W., Kim, E.J., Hong Lim, J., Cho, C., Shin Ryu, Y., Kuk Lee, S., Lee, S.Y., Kim, K.J.
Nat Commun