CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Serine hydroxymethyltransferase

Enzyme Information

2.1.2.1
Glycine hydroxymethyltransferase.
based on mapping to UniProt Q5M0B4
5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.
-!- Also catalyzes the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy- N(6),N(6),N(6)-trimethyl-L-lysine.

UniProtKB Entries (1)

Q5M0B4
GLYA_STRT1
Streptococcus thermophilus CNRZ1066
Serine hydroxymethyltransferase

PDB Structure

PDB 4WXB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Engineered L-Serine Hydroxymethyltransferase from Streptococcus thermophilus for the Synthesis of alpha , alpha-Dialkyl-alpha-Amino Acids.
Hernandez, K., Zelen, I., Petrillo, G., Uson, I., Wandtke, C.M., Bujons, J., Joglar, J., Parella, T., Clapes, P.
Angew.Chem.Int.Ed.Engl.