1 keywords

CATH Domain 4wvlA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.150 Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Histone-lysine N-methyltransferase, H3 lysine-79 specific

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q8TEK3
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q8TEK3
DOT1L_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase, H3 lysine-79 specific

PDB Structure

PDB 4WVL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement.
Yi, J.S., Federation, A.J., Qi, J., Dhe-Paganon, S., Hadler, M., Xu, X., St Pierre, R., Varca, A.C., Wu, L., Marineau, J.J., Smith, W.B., Souza, A., Chory, E.J., Armstrong, S.A., Bradner, J.E.
Acs Chem.Biol.