CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.460.40
Functional Family

Enzyme Information

2.7.7.46
Gentamicin 2''-nucleotidyltransferase.
based on mapping to UniProt P0AE05
Nucleoside triphosphate + gentamicin = diphosphate + 2''-nucleotidylgentamicin.
-!- ATP, dATP, CTP, ITP and GTP can act as donors. -!- Kanamycin, tobramycin and sisomicin can also act as acceptors. -!- The nucleotidyl residue is transferred to the 2-hydroxy group of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.

UniProtKB Entries (1)

P0AE05
AADB1_KLEPN
Klebsiella pneumoniae
2''-aminoglycoside nucleotidyltransferase

PDB Structure

PDB 4WQL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2)-Ia.
Cox, G., Stogios, P.J., Savchenko, A., Wright, G.D.
Mbio