CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.420.40
Functional Family tRNA N6-adenosine threonylcarbamoyltransferase

Enzyme Information

2.3.1.234
N(6)-L-threonylcarbamoyladenine synthase.
based on mapping to UniProt P05852
L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L- threonylcarbamoyladenine(37) in tRNA.
-!- The enzyme is involved in the synthesis of N(6)- threonylcarbamoyladenosine(37) in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNA(Ile), tRNA(Thr), tRNA(Asn), tRNA(Lys), tRNA(Ser) and tRNA(Arg). -!- Formerly EC 2.6.99.4.

UniProtKB Entries (1)

P05852
TSAD_ECOLI
Escherichia coli K-12
TRNA N6-adenosine threonylcarbamoyltransferase

PDB Structure

PDB 4WQ4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The ATP-mediated formation of the YgjD-YeaZ-YjeE complex is required for the biosynthesis of tRNA t6A in Escherichia coli.
Zhang, W., Collinet, B., Perrochia, L., Durand, D., van Tilbeurgh, H.
Nucleic Acids Res.