CATH Classification

Domain Context

CATH Clusters

Superfamily Aldehyde Dehydrogenase; Chain A, domain 2
Functional Family Mitochondrial aldehyde dehydrogenase 2

Enzyme Information

1.2.1.36
Retinal dehydrogenase.
based on mapping to UniProt P00352
Retinal + NAD(+) + H(2)O = retinoate + NADH.
-!- Acts on both the 11-trans- and 13-cis-forms of retinal.
1.2.1.-
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt P00352

UniProtKB Entries (1)

P00352
AL1A1_HUMAN
Homo sapiens
Retinal dehydrogenase 1

PDB Structure

PDB 4WPN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Characterization of Two Distinct Structural Classes of Selective Aldehyde Dehydrogenase 1A1 Inhibitors.
Morgan, C.A., Hurley, T.D.
J.Med.Chem.