CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.390 | Collagenase (Catalytic Domain) |
|
3.40.390.10 | Collagenase (Catalytic Domain) |
Domain Context
CATH Clusters
| Superfamily | Collagenase (Catalytic Domain) |
| Functional Family | A disintegrin and metalloproteinase with thrombospondin motifs 1 |
Enzyme Information
| 3.4.24.82 |
ADAMTS-4 endopeptidase.
based on mapping to UniProt O75173
Glutamyl endopeptidase. Bonds cleaved include 370-Thr-Glu-Gly-Glu-|-Ala- Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan.
-!- Thought to be biologically significant for the degradation of the aggrecan component of cartilage matrix. -!- Belongs to peptidase family M12.
|
UniProtKB Entries (1)
| O75173 |
ATS4_HUMAN
Homo sapiens
A disintegrin and metalloproteinase with thrombospondin motifs 4
|
PDB Structure
| PDB | 4WKE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
J.Med.Chem.
|