CATH Classification

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family Bifunctional ligase/repressor BirA

Enzyme Information

6.3.4.15
Biotin--[biotin carboxyl-carrier protein] ligase.
based on mapping to UniProt P06709
ATP + biotin + [biotin carboxyl-carrier protein]-L-lysine = AMP + diphosphate + [biotin carboxyl-carrier protein]-N(6)-biotinyl-L-lysine.
-!- The enzyme biotinylates a biotin carboxyl-carrier protein that is part of an acetyl-CoA carboxylase complex, enabling its subsequent carboxylation by EC 6.3.4.14. -!- The carboxyl group is eventually transferred to acetyl-CoA by EC 2.1.3.15. -!- In some organisms the carrier protein is part of EC 6.4.1.2.

UniProtKB Entries (1)

P06709
BIRA_ECOLI
Escherichia coli K-12
Bifunctional ligase/repressor BirA

PDB Structure

PDB 4WF2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Allosteric Coupling via Distant Disorder-to-Order Transitions.
Eginton, C., Cressman, W.J., Bachas, S., Wade, H., Beckett, D.
J.Mol.Biol.