1 keywords

CATH Domain 4w1vA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.640 Aspartate Aminotransferase; domain 2
Homologous Superfamily 3.40.640.10 Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Enzyme Information

2.6.1.62
Adenosylmethionine--8-amino-7-oxononanoate transaminase.
based on mapping to UniProt P9WQ80
S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4- methylthio-2-oxobutanoate + 7,8-diaminononanoate.
-!- S-adenosylhomocysteine can also act as donor.

UniProtKB Entries (1)

P9WQ80
BIOA_MYCTO
Mycobacterium tuberculosis CDC1551
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

PDB Structure

PDB 4W1V
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis.
Park, S.W., Casalena, D.E., Wilson, D.J., Dai, R., Nag, P.P., Liu, F., Boyce, J.P., Bittker, J.A., Schreiber, S.L., Finzel, B.C., Schnappinger, D., Aldrich, C.C.
Chem.Biol.