CATH Classification

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.53
3',5'-cyclic-AMP phosphodiesterase.
based on mapping to UniProt Q08499
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
-!- Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35). -!- It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation. -!- Formerly EC 3.1.4.n1.

UniProtKB Entries (1)

Q08499
PDE4D_HUMAN
Homo sapiens
CAMP-specific 3',5'-cyclic phosphodiesterase 4D

PDB Structure

PDB 4W1O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery and Early Clinical Development of 2-{6-[2-(3,5-Dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a Soft-Drug Inhibitor of Phosphodiesterase 4 for Topical Treatment of Atopic Dermatitis
Felding, J., Sorensen, M.D., Poulsen, T.D., Larsen, J., Andersson, C., Refer, P., Engell, K., Ladgefoged, L.G., Thormann, T., Vinggaard, A.M., Hegardt, P., Sohoel, A., Nielse, S.F.
J.Med.Chem