CATH Classification

Domain Context

CATH Clusters

Superfamily Probable inorganic polyphosphate/atp-NAD kinase; domain 1
Functional Family Sphingosine kinase 2

Enzyme Information

2.7.1.91
Sphingosine kinase.
based on mapping to UniProt Q9NYA1
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate.
-!- The enzyme is involved in the production of sphingolipid metabolites. -!- It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo- dihydrosphingosine. -!- The exact substrate range depends on the species.
2.3.1.-
Transferring groups other than amino-acyl groups.
based on mapping to UniProt Q9NYA1

UniProtKB Entries (1)

Q9NYA1
SPHK1_HUMAN
Homo sapiens
Sphingosine kinase 1

PDB Structure

PDB 4V24
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Sphingosine Kinase 1 with Pf-543.
Wang, J., Knapp, S., Pyne, N.J., Pyne, S., Elkins, J.M.
Acs Med.Chem.Lett.