CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Fibroblast growth factor receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P11362
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P11362
FGFR1_HUMAN
Homo sapiens
Fibroblast growth factor receptor 1

PDB Structure

PDB 4UWY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study
Bunney, T., Wan, S., Thiyagarajan, N., Sutto, L., Williams, S.V., Ashford, P., Koss, H., Knowles, M.A., Gervasio, F.L., Coveney, P.V., Katan, M.
Ebiomedicine