CATH Classification

Domain Context

CATH Clusters

Superfamily CBS-domain
Functional Family Cystathionine beta-synthase

Enzyme Information

4.2.1.22
Cystathionine beta-synthase.
based on mapping to UniProt P35520
L-serine + L-homocysteine = L-cystathionine + H(2)O.
-!- A multifunctional enzyme: catalyzes beta-replacement reaction between L-serine, L-cysteine, cysteine thioethers or some other beta- substituted alpha-L-amino acids and a variety of mercaptans. -!- Formerly EC 4.2.1.21.

UniProtKB Entries (1)

P35520
CBS_HUMAN
Homo sapiens
Cystathionine beta-synthase

PDB Structure

PDB 4UUU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation.
Mccorvie, T.J., Kopec, J., Hyung, S., Fitzpatrick, F., Feng, X., Termine, D., Strain-Damerell, C., Vollmar, M., Fleming, J., Janz, J.M., Bulawa, C., Yue, W.W.
J.Biol.Chem.