CATH Domain 4umyA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.718	Isopropylmalate Dehydrogenase
	3.40.718.10	Isopropylmalate Dehydrogenase

Domain Context

CATH Clusters

Superfamily	Isopropylmalate Dehydrogenase
Functional Family	Isocitrate dehydrogenase [NADP]

Enzyme Information

1.1.1.42

Isocitrate dehydrogenase (NADP(+)).

based on mapping to UniProt O75874

Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.

-!- Unlike EC 1.1.1.41, oxalosuccinate can be used as a substrate. -!- In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm. -!- The enzyme from some species can also use NAD(+) but much more slowly.

UniProtKB Entries (1)

O75874

IDHC_HUMAN

Homo sapiens

Isocitrate dehydrogenase [NADP] cytoplasmic

PDB Structure

PDB	4UMY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (Idh1) Via Disruption of a Metal Binding Network by an Allosteric Small Molecule. Deng, G., Shen, J., Yin, M., Mcmanus, J., Mathieu, M., Gee, P., He, T., Shi, C., Bedel, O., Mclean, L.R., Le-Strat, F., Zhang, Y., Marquette, J., Gao, Q., Zhang, B., Rak, A., Hoffmann, D., Rooney, E., Vassort, A., Englaro, W., Li, Y., Patel, V., Adrian, F., Gross, S., Wiederschain, D., Cheng, H., Licht, S. J.Biol.Chem.