CATH Classification

Domain Context

CATH Clusters

Superfamily Nitric Oxide Synthase;Heme Domain;Chain A domain 2
Functional Family

Enzyme Information

1.14.13.165
Nitric-oxide synthase (NAD(P)H).
based on mapping to UniProt O34453
2 L-arginine + 3 NAD(P)H + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NAD(P)(+) + 4 H(2)O.
-!- Most of the bacterial and archaeal enzymes consist of only an oxidase domain and function together with bacterial ferredoxins. -!- The enzyme from the delta-proteobacterium Sorangium cellulosum also includes a reductase domain that binds FAD, FMN and a [2Fe-2S] cluster. -!- The similar enzymes from plants and animals use only NADPH as acceptor (cf. EC 1.14.13.39).

UniProtKB Entries (1)

O34453
NOSO_BACSU
Bacillus subtilis subsp. subtilis str. 168
Nitric oxide synthase oxygenase

PDB Structure

PDB 4UGD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.
Holden, J.K., Dejam, D., Lewis, M.C., Huang, H., Kang, S., Jing, Q., Xue, F., Silverman, R.B., Poulos, T.L.
Biochemistry